Adipsia after Oclacitinib (Apoquel) in dogs

The FDA has received 74 reports of adipsia in dogs after Oclacitinib. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

74Reports

46%Marked serious

23%Recovered

11%Died or euthanised

5 daysTypical onset

How soon it started

Same day

17 29%

1–2 days

8 14%

3–7 days

5 8.6%

1–4 weeks

11 19%

Over a month

17 29%

How the animals did

Recovered

17 23%

Still unwell when reported

31 42%

Died

3 4.1%

Euthanised

5 6.8%

Not known

18 24%

Problems reported at the same time

66 89%

42 57%

25 34%

15 20%

15 20%

12 16%

Didn't work as expected

10 14%

Kidney problems

10 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause adipsia in dogs?: 74 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Adipsia with similar medicines

Adipsia after Cyclosporine (Atopica) 38 reports · 0.2% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with adipsia