Unable to stand after Moxidectin (ProHeart 6) in dogs

132 reports to the FDA describe unable to stand in dogs given Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

132Reports

83%Marked serious

30%Recovered

23%Died or euthanised

Same dayTypical onset

How soon it started

Same day

91 71%

1–2 days

16 13%

3–7 days

8 6.3%

1–4 weeks

7 5.5%

Over a month

6 4.7%

How the animals did

Recovered

39 30%

Still unwell when reported

58 44%

Died

17 13%

Euthanised

13 9.8%

Not known

5 3.8%

Problems reported at the same time

62 47%

60 45%

53 40%

34 26%

31 23%

30 23%

30 23%

27 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause unable to stand in dogs?: 132 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unable to stand with similar medicines

Unable to stand after Ivermectin + Pyrantel (Heartgard Plus) 198 reports · 0.1% of its reports
Unable to stand after Milbemycin Oxime + Spinosad (Trifexis) 419 reports · 0.3% of its reports
Unable to stand after Milbemycin Oxime + Praziquantel (Interceptor Plus) 76 reports · 0.2% of its reports
Unable to stand after Milbemycin Oxime (Interceptor) 28 reports · 0.1% of its reports
Unable to stand after Selamectin (Revolution) 39 reports · 0.1% of its reports
Unable to stand after Ivermectin (Heartgard) 67 reports · 0.6% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with unable to stand