Unable to stand after Milbemycin Oxime + Spinosad (Trifexis) in dogs

419 reports to the FDA describe unable to stand in dogs given Milbemycin Oxime + Spinosad. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

419Reports

56%Marked serious

55%Recovered

17%Died or euthanised

1 daysTypical onset

How soon it started

Same day

135 43%

1–2 days

45 14%

3–7 days

11 3.5%

1–4 weeks

16 5.0%

Over a month

110 35%

How the animals did

Recovered

183 44%

Recovered with lasting effects

47 11%

Still unwell when reported

45 11%

Died

23 5.5%

Euthanised

48 11%

Not known

73 17%

Problems reported at the same time

203 48%

141 34%

124 30%

120 29%

86 21%

76 18%

72 17%

71 17%

Age of the animals

Under 1 year

1–3 years

100

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Spinosad kills fleas; monthly chewable.

Products with this combination include Trifexis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Spinosad cause unable to stand in dogs?: 419 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unable to stand with similar medicines

Unable to stand after Ivermectin + Pyrantel (Heartgard Plus) 198 reports · 0.1% of its reports
Unable to stand after Moxidectin (ProHeart 6) 132 reports · 0.3% of its reports
Unable to stand after Milbemycin Oxime + Praziquantel (Interceptor Plus) 76 reports · 0.2% of its reports
Unable to stand after Milbemycin Oxime (Interceptor) 28 reports · 0.1% of its reports
Unable to stand after Selamectin (Revolution) 39 reports · 0.1% of its reports
Unable to stand after Ivermectin (Heartgard) 67 reports · 0.6% of its reports

All reported side effects of Milbemycin Oxime + Spinosad in dogs · Medicines most reported with unable to stand