Not drinking after Moxidectin (ProHeart 6) in dogs

The FDA has received 169 reports of not drinking in dogs after Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

169Reports

70%Marked serious

13%Recovered

28%Died or euthanised

1 daysTypical onset

How soon it started

Same day

60 39%

1–2 days

44 29%

3–7 days

19 12%

1–4 weeks

15 9.7%

Over a month

16 10%

How the animals did

Recovered

21 12%

Recovered with lasting effects

1 0.6%

Still unwell when reported

88 52%

Died

17 10%

Euthanised

30 18%

Not known

12 7.1%

Problems reported at the same time

147 87%

111 66%

72 43%

47 28%

47 28%

33 20%

25 15%

24 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause not drinking in dogs?: 169 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not drinking with similar medicines

Not drinking after Ivermectin + Pyrantel (Heartgard Plus) 282 reports · 0.2% of its reports
Not drinking after Milbemycin Oxime + Spinosad (Trifexis) 962 reports · 0.7% of its reports
Not drinking after Milbemycin Oxime + Praziquantel (Interceptor Plus) 187 reports · 0.6% of its reports
Not drinking after Milbemycin Oxime (Interceptor) 43 reports · 0.1% of its reports
Not drinking after Selamectin (Revolution) 42 reports · 0.1% of its reports
Not drinking after Ivermectin (Heartgard) 48 reports · 0.4% of its reports
Not drinking after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 41 reports · 0.5% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with not drinking