Not drinking after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

187 reports to the FDA describe not drinking in dogs given Milbemycin Oxime + Praziquantel. That is 0.6% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

187Reports

33%Marked serious

34%Recovered

8.6%Died or euthanised

2 daysTypical onset

How soon it started

Same day

49 33%

1–2 days

30 20%

3–7 days

18 12%

1–4 weeks

12 8.1%

Over a month

40 27%

How the animals did

Recovered

63 34%

Still unwell when reported

61 33%

Died

6 3.2%

Euthanised

10 5.3%

Not known

47 25%

Problems reported at the same time

168 90%

121 65%

88 47%

53 28%

29 16%

28 15%

24 13%

23 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause not drinking in dogs?: 187 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not drinking with similar medicines

Not drinking after Ivermectin + Pyrantel (Heartgard Plus) 282 reports · 0.2% of its reports
Not drinking after Milbemycin Oxime + Spinosad (Trifexis) 962 reports · 0.7% of its reports
Not drinking after Moxidectin (ProHeart 6) 169 reports · 0.3% of its reports
Not drinking after Milbemycin Oxime (Interceptor) 43 reports · 0.1% of its reports
Not drinking after Selamectin (Revolution) 42 reports · 0.1% of its reports
Not drinking after Ivermectin (Heartgard) 48 reports · 0.4% of its reports
Not drinking after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 41 reports · 0.5% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with not drinking