Not drinking after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) in dogs

The FDA has received 41 reports of not drinking in dogs after Ivermectin + Praziquantel + Pyrantel. That is 0.5% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

41Reports

66%Marked serious

46%Recovered

17%Died or euthanised

Same dayTypical onset

How soon it started

Same day

22 54%

1–2 days

9 22%

3–7 days

1 2.4%

1–4 weeks

4 9.8%

Over a month

5 12%

How the animals did

Recovered

19 46%

Still unwell when reported

2 4.9%

Died

5 12%

Euthanised

2 4.9%

Not known

13 32%

Problems reported at the same time

32 78%

25 61%

17 41%

9 22%

9 22%

6 15%

6 15%

5 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Iverhart Max. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel + Pyrantel cause not drinking in dogs?: 41 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not drinking with similar medicines

Not drinking after Ivermectin + Pyrantel (Heartgard Plus) 282 reports · 0.2% of its reports
Not drinking after Milbemycin Oxime + Spinosad (Trifexis) 962 reports · 0.7% of its reports
Not drinking after Moxidectin (ProHeart 6) 169 reports · 0.3% of its reports
Not drinking after Milbemycin Oxime + Praziquantel (Interceptor Plus) 187 reports · 0.6% of its reports
Not drinking after Milbemycin Oxime (Interceptor) 43 reports · 0.1% of its reports
Not drinking after Selamectin (Revolution) 42 reports · 0.1% of its reports
Not drinking after Ivermectin (Heartgard) 48 reports · 0.4% of its reports

All reported side effects of Ivermectin + Praziquantel + Pyrantel in dogs · Medicines most reported with not drinking