Drug dose omission after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

399 reports to the FDA describe drug dose omission in dogs given Milbemycin Oxime + Praziquantel. That is 1.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

399Reports

4.5%Marked serious

2.8%Recovered

0.0%Died or euthanised

152 daysTypical onset

How soon it started

Same day

9 8.5%

1–2 days

4 3.8%

3–7 days

3 2.8%

1–4 weeks

7 6.6%

Over a month

83 78%

How the animals did

Recovered

10 2.5%

Recovered with lasting effects

1 0.3%

Still unwell when reported

20 5.0%

Not known

368 92%

Problems reported at the same time

Didn't prevent heartworm

327 82%

Didn't stop worms

44 11%

Vomiting

16 4.0%

Weight gain

13 3.3%

Didn't work as expected

13 3.3%

Cough

12 3.0%

Underdose

9 2.3%

Lethargy

9 2.3%

Age of the animals

Under 1 year

1–3 years

175

4–7 years

118

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause drug dose omission in dogs?: 399 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 152 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose omission with similar medicines

Drug dose omission after Ivermectin + Pyrantel (Heartgard Plus) 503 reports · 0.3% of its reports
Drug dose omission after Milbemycin Oxime + Spinosad (Trifexis) 1,201 reports · 0.9% of its reports
Drug dose omission after Moxidectin (ProHeart 6) 53 reports · 0.1% of its reports
Drug dose omission after Milbemycin Oxime (Interceptor) 109 reports · 0.4% of its reports
Drug dose omission after Selamectin (Revolution) 87 reports · 0.3% of its reports
Drug dose omission after Ivermectin (Heartgard) 72 reports · 0.6% of its reports
Drug dose omission after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 87 reports · 1.0% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with drug dose omission