Drug dose omission after Moxidectin (ProHeart 6) in dogs

The FDA has received 53 reports of drug dose omission in dogs after Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

53Reports

51%Marked serious

9.4%Recovered

3.8%Died or euthanised

315 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

1 10%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

9 90%

How the animals did

Recovered

5 9.4%

Still unwell when reported

24 45%

Died

2 3.8%

Not known

22 42%

Problems reported at the same time

Didn't prevent heartworm

35 66%

Didn't stop worms

11 21%

Medication error

8 15%

Drug dose administration interval too long

5 9.4%

3 5.7%

2 3.8%

2 3.8%

2 3.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause drug dose omission in dogs?: 53 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 315 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose omission with similar medicines

Drug dose omission after Ivermectin + Pyrantel (Heartgard Plus) 503 reports · 0.3% of its reports
Drug dose omission after Milbemycin Oxime + Spinosad (Trifexis) 1,201 reports · 0.9% of its reports
Drug dose omission after Milbemycin Oxime + Praziquantel (Interceptor Plus) 399 reports · 1.3% of its reports
Drug dose omission after Milbemycin Oxime (Interceptor) 109 reports · 0.4% of its reports
Drug dose omission after Selamectin (Revolution) 87 reports · 0.3% of its reports
Drug dose omission after Ivermectin (Heartgard) 72 reports · 0.6% of its reports
Drug dose omission after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 87 reports · 1.0% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with drug dose omission