Medication error after Moxidectin (ProHeart 6) in dogs

The FDA has received 1,478 reports of medication error in dogs after Moxidectin. That is 2.9% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,478Reports

96%Marked serious

3.6%Recovered

1.0%Died or euthanised

179 daysTypical onset

How soon it started

Same day

44 8.7%

1–2 days

15 3.0%

3–7 days

8 1.6%

1–4 weeks

26 5.1%

Over a month

415 82%

How the animals did

Recovered

53 3.6%

Still unwell when reported

1,357 92%

Died

10 0.7%

Euthanised

5 0.3%

Not known

53 3.6%

Problems reported at the same time

Didn't stop worms

841 57%

Didn't prevent heartworm

537 36%

Drug dose administration interval too long

107 7.2%

Intentional misuse

86 5.8%

Drug dose administration interval too short

69 4.7%

Didn't work as expected

46 3.1%

Overdose

37 2.5%

Vomiting

37 2.5%

Age of the animals

Under 1 year

1–3 years

467

4–7 years

530

8–11 years

329

12+ years

107

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause medication error in dogs?: 1,478 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 179 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Medication error with similar medicines

Medication error after Ivermectin + Pyrantel (Heartgard Plus) 135 reports · 0.1% of its reports
Medication error after Milbemycin Oxime + Spinosad (Trifexis) 47 reports · 0.0% of its reports
Medication error after Milbemycin Oxime + Praziquantel (Interceptor Plus) 63 reports · 0.2% of its reports
Medication error after Selamectin (Revolution) 50 reports · 0.2% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with medication error