Drug dose omission after Selamectin (Revolution) in dogs

The FDA has received 87 reports of drug dose omission in dogs after Selamectin. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

87Reports

22%Marked serious

2.3%Recovered

1.1%Died or euthanised

92 daysTypical onset

How soon it started

Same day

1 8.3%

1–2 days

1 8.3%

3–7 days

1 8.3%

1–4 weeks

0 0.0%

Over a month

9 75%

How the animals did

Recovered

2 2.3%

Still unwell when reported

59 68%

Euthanised

1 1.1%

Not known

25 29%

Problems reported at the same time

Didn't prevent heartworm

69 79%

8 9.2%

6 6.9%

4 4.6%

4 4.6%

Didn't work as expected

4 4.6%

Medication error

4 4.6%

Loss of appetite

3 3.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause drug dose omission in dogs?: 87 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 92 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose omission with similar medicines

Drug dose omission after Ivermectin + Pyrantel (Heartgard Plus) 503 reports · 0.3% of its reports
Drug dose omission after Milbemycin Oxime + Spinosad (Trifexis) 1,201 reports · 0.9% of its reports
Drug dose omission after Moxidectin (ProHeart 6) 53 reports · 0.1% of its reports
Drug dose omission after Milbemycin Oxime + Praziquantel (Interceptor Plus) 399 reports · 1.3% of its reports
Drug dose omission after Milbemycin Oxime (Interceptor) 109 reports · 0.4% of its reports
Drug dose omission after Ivermectin (Heartgard) 72 reports · 0.6% of its reports
Drug dose omission after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 87 reports · 1.0% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with drug dose omission