Inappropriate urination after Melarsomine (Immiticide) in dogs

The FDA has received 86 reports of inappropriate urination in dogs after Melarsomine. That is 0.4% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

86Reports

71%Marked serious

22%Recovered

5.8%Died or euthanised

6 daysTypical onset

How soon it started

Same day

24 28%

1–2 days

9 11%

3–7 days

11 13%

1–4 weeks

20 24%

Over a month

21 25%

How the animals did

Recovered

18 21%

Recovered with lasting effects

1 1.2%

Still unwell when reported

26 30%

Died

4 4.7%

Euthanised

1 1.2%

Not known

36 42%

Problems reported at the same time

Inappropriate defecation

23 27%

19 22%

19 22%

15 17%

13 15%

12 14%

11 13%

11 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Melarsomine treats adult heartworm infection (a series of injections given by a vet).

Products with this ingredient include Immiticide, Diroban. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Melarsomine cause inappropriate urination in dogs?: 86 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Inappropriate urination with similar medicines

Inappropriate urination after Polysulfated Glycosaminoglycan 49 reports · 0.9% of its reports
Inappropriate urination after Diphenhydramine 70 reports · 1.5% of its reports
Inappropriate urination after Butorphanol 42 reports · 0.9% of its reports
Inappropriate urination after Cefpodoxime 56 reports · 1.4% of its reports
Inappropriate urination after Tramadol 79 reports · 2.1% of its reports
Inappropriate urination after Florfenicol + Mometasone + Terbinafine 49 reports · 1.4% of its reports
Inappropriate urination after Desoxycorticosterone Pivalate 74 reports · 2.2% of its reports
Inappropriate urination after Propofol 22 reports · 0.7% of its reports
Inappropriate urination after Isoflurane 28 reports · 1.0% of its reports
Inappropriate urination after Cephalexin 26 reports · 1.0% of its reports

All reported side effects of Melarsomine in dogs · Medicines most reported with inappropriate urination