Inappropriate defecation after Melarsomine (Immiticide) in dogs

The FDA has received 83 reports of inappropriate defecation in dogs after Melarsomine. That is 0.4% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

83Reports
83%Marked serious
20%Recovered
7.2%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
32 40%
1–2 days
2 2.5%
3–7 days
9 11%
1–4 weeks
15 19%
Over a month
23 28%

How the animals did

Recovered
17 20%
Still unwell when reported
36 43%
Died
5 6.0%
Euthanised
1 1.2%
Not known
24 29%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
43
4–7 years
28
8–11 years
7
12+ years
4

About this medicine

Melarsomine treats adult heartworm infection (a series of injections given by a vet).

Products with this ingredient include Immiticide, Diroban. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Melarsomine cause inappropriate defecation in dogs?
83 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Inappropriate defecation with similar medicines

All reported side effects of Melarsomine in dogs · Medicines most reported with inappropriate defecation