Stiffness after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

23 reports to the FDA describe stiffness in dogs given Lufenuron + Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

23Reports

78%Marked serious

52%Recovered

4.3%Died or euthanised

1 daysTypical onset

How soon it started

Same day

5 45%

1–2 days

2 18%

3–7 days

2 18%

1–4 weeks

0 0.0%

Over a month

2 18%

How the animals did

Recovered

11 48%

Recovered with lasting effects

1 4.3%

Still unwell when reported

5 22%

Died

1 4.3%

Not known

5 22%

Problems reported at the same time

7 30%

7 30%

7 30%

7 30%

6 26%

5 22%

5 22%

4 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause stiffness in dogs?: 23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Stiffness with similar medicines

Stiffness after Spinosad (Comfortis) 51 reports · 0.1% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with stiffness