Regurgitation after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

22 reports to the FDA describe regurgitation in dogs given Lufenuron + Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.

22Reports

55%Marked serious

45%Recovered

14%Died or euthanised

2 daysTypical onset

How soon it started

Same day

3 25%

1–2 days

4 33%

3–7 days

0 0.0%

1–4 weeks

1 8.3%

Over a month

4 33%

How the animals did

Recovered

10 45%

Still unwell when reported

3 14%

Died

3 14%

Not known

6 27%

Problems reported at the same time

11 50%

9 41%

9 41%

9 41%

Abnormal radiograph finding

5 23%

Behaviour change

4 18%

Abnormal ultrasound finding

4 18%

Didn't work as expected

4 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause regurgitation in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Regurgitation with similar medicines

Regurgitation after Spinosad (Comfortis) 27 reports · 0.0% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with regurgitation