Heart murmur after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 28 reports of heart murmur in dogs after Lufenuron + Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

28Reports

96%Marked serious

29%Recovered

21%Died or euthanised

–Typical onset

How the animals did

Recovered

2 7.1%

Recovered with lasting effects

6 21%

Still unwell when reported

5 18%

Died

2 7.1%

Euthanised

4 14%

Not known

9 32%

Problems reported at the same time

8 29%

7 25%

7 25%

6 21%

6 21%

6 21%

6 21%

Didn't prevent heartworm

5 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause heart murmur in dogs?: 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Heart murmur with similar medicines

Heart murmur after Spinosad (Comfortis) 67 reports · 0.1% of its reports
Heart murmur after Imidacloprid + Moxidectin (Advantage Multi) 30 reports · 0.2% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with heart murmur