Anxiety after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

113 reports to the FDA describe anxiety in dogs given Lufenuron + Milbemycin Oxime. That is 0.4% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

113Reports

59%Marked serious

51%Recovered

7.1%Died or euthanised

1 daysTypical onset

How soon it started

Same day

23 34%

1–2 days

11 16%

3–7 days

5 7.5%

1–4 weeks

7 10%

Over a month

21 31%

How the animals did

Recovered

57 50%

Recovered with lasting effects

1 0.9%

Still unwell when reported

26 23%

Died

2 1.8%

Euthanised

6 5.3%

Not known

21 19%

Problems reported at the same time

Breathing problems

32 28%

Lethargy

30 27%

Itching

28 25%

Restlessness or agitation

26 23%

26 23%

25 22%

23 20%

22 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause anxiety in dogs?: 113 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Anxiety with similar medicines

Anxiety after Spinosad (Comfortis) 141 reports · 0.2% of its reports
Anxiety after Imidacloprid + Moxidectin (Advantage Multi) 103 reports · 0.8% of its reports
Anxiety after Nitenpyram (Capstar) 63 reports · 0.6% of its reports
Anxiety after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 36 reports · 0.4% of its reports
Anxiety after Fipronil + S-methoprene (Frontline Plus) 36 reports · 1.2% of its reports
Anxiety after Flumethrin + Imidacloprid (Seresto) 23 reports · 1.0% of its reports
Anxiety after Fipronil 23 reports · 1.6% of its reports
Anxiety after Cyphenothrin + Fipronil + S-methoprene 39 reports · 6.0% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with anxiety