Inappropriate urination after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 27 reports of inappropriate urination in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.3% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

27Reports

59%Marked serious

48%Recovered

7.4%Died or euthanised

Same dayTypical onset

How soon it started

Same day

10 53%

1–2 days

4 21%

3–7 days

3 16%

1–4 weeks

1 5.3%

Over a month

1 5.3%

How the animals did

Recovered

13 48%

Still unwell when reported

6 22%

Died

1 3.7%

Euthanised

1 3.7%

Not known

6 22%

Problems reported at the same time

7 26%

7 26%

6 22%

6 22%

5 19%

4 15%

4 15%

Inappropriate defecation

4 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause inappropriate urination in dogs?: 27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Inappropriate urination with similar medicines

Inappropriate urination after Spinosad (Comfortis) 140 reports · 0.2% of its reports
Inappropriate urination after Lufenuron + Milbemycin Oxime (Sentinel) 59 reports · 0.2% of its reports
Inappropriate urination after Imidacloprid + Moxidectin (Advantage Multi) 76 reports · 0.6% of its reports
Inappropriate urination after Nitenpyram (Capstar) 28 reports · 0.3% of its reports
Inappropriate urination after Fipronil + S-methoprene (Frontline Plus) 24 reports · 0.8% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with inappropriate urination