Eye or vision problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 22 reports of eye or vision problems in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.2% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

22Reports

100%Marked serious

50%Recovered

0.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

8 62%

1–2 days

3 23%

3–7 days

0 0.0%

1–4 weeks

1 7.7%

Over a month

1 7.7%

How the animals did

Recovered

4 18%

Recovered with lasting effects

7 32%

Still unwell when reported

5 23%

Not known

6 27%

Problems reported at the same time

Wobbliness (ataxia)

7 32%

Abnormal pupil light reflex

6 27%

Tremors

6 27%

Dilated pupils

5 23%

Lethargy

5 23%

Retinal detachment

4 18%

Abnormal menace reflex test

3 14%

Behaviour change

3 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause eye or vision problems in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eye or vision problems with similar medicines

Eye or vision problems after Spinosad (Comfortis) 497 reports · 0.9% of its reports
Eye or vision problems after Lufenuron + Milbemycin Oxime (Sentinel) 68 reports · 0.3% of its reports
Eye or vision problems after Imidacloprid + Moxidectin (Advantage Multi) 180 reports · 1.4% of its reports
Eye or vision problems after Nitenpyram (Capstar) 42 reports · 0.4% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with eye or vision problems