Eye or vision problems after Imidacloprid + Moxidectin (Advantage Multi) in dogs

180 reports to the FDA describe eye or vision problems in dogs given Imidacloprid + Moxidectin. That is 1.4% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

180Reports

67%Marked serious

30%Recovered

6.7%Died or euthanised

Same dayTypical onset

How soon it started

Same day

65 58%

1–2 days

30 27%

3–7 days

4 3.5%

1–4 weeks

11 9.7%

Over a month

3 2.7%

How the animals did

Recovered

53 29%

Recovered with lasting effects

1 0.6%

Still unwell when reported

4 2.2%

Died

5 2.8%

Euthanised

7 3.9%

Not known

110 61%

Problems reported at the same time

73 41%

61 34%

44 24%

37 21%

Restlessness or agitation

29 16%

Behaviour change

26 14%

Vomiting

25 14%

Breathing problems

23 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause eye or vision problems in dogs?: 180 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eye or vision problems with similar medicines

Eye or vision problems after Spinosad (Comfortis) 497 reports · 0.9% of its reports
Eye or vision problems after Lufenuron + Milbemycin Oxime (Sentinel) 68 reports · 0.3% of its reports
Eye or vision problems after Nitenpyram (Capstar) 42 reports · 0.4% of its reports
Eye or vision problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 22 reports · 0.2% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with eye or vision problems