Behaviour change after Lokivetmab (Cytopoint) in dogs

289 reports to the FDA describe behaviour change in dogs given Lokivetmab. That is 4.4% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

289Reports

47%Marked serious

18%Recovered

13%Died or euthanised

4 daysTypical onset

How soon it started

Same day

60 27%

1–2 days

41 18%

3–7 days

23 10%

1–4 weeks

39 17%

Over a month

63 28%

How the animals did

Recovered

53 18%

Still unwell when reported

145 50%

Died

13 4.5%

Euthanised

24 8.3%

Not known

54 19%

Problems reported at the same time

Lethargy

83 29%

Loss of appetite

78 27%

Didn't work as expected

64 22%

63 22%

39 13%

38 13%

37 13%

35 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lokivetmab controls allergic itch for 4–8 weeks per injection.

Products with this ingredient include Cytopoint. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lokivetmab cause behaviour change in dogs?: 289 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

Behaviour change after Bedinvetmab (Librela) 673 reports · 3.4% of its reports

All reported side effects of Lokivetmab in dogs · Medicines most reported with behaviour change