Neutropenia after Ketoconazole in dogs

55 reports to the FDA describe neutropenia in dogs given Ketoconazole. That is 2.4% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

55Reports
36%Marked serious
15%Recovered
16%Died or euthanised
68 daysTypical onset
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How soon it started

Same day
1 2.1%
1–2 days
2 4.2%
3–7 days
1 2.1%
1–4 weeks
6 13%
Over a month
38 79%

How the animals did

Recovered
8 15%
Still unwell when reported
28 51%
Died
4 7.3%
Euthanised
5 9.1%
Not known
10 18%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
14
4–7 years
25
8–11 years
12
12+ years
4

About this medicine

Type: medicine.

Questions owners ask

Can Ketoconazole cause neutropenia in dogs?
55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 68 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutropenia with similar medicines

All reported side effects of Ketoconazole in dogs · Medicines most reported with neutropenia