Eosinopenia after Ketoconazole in dogs

The FDA has received 30 reports of eosinopenia in dogs after Ketoconazole. That is 1.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

30Reports
47%Marked serious
20%Recovered
10%Died or euthanised
111 daysTypical onset
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How soon it started

Same day
3 10%
1–2 days
0 0.0%
3–7 days
0 0.0%
1–4 weeks
5 17%
Over a month
21 72%

How the animals did

Recovered
5 17%
Recovered with lasting effects
1 3.3%
Still unwell when reported
14 47%
Died
2 6.7%
Euthanised
1 3.3%
Not known
7 23%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
6
4–7 years
14
8–11 years
9
12+ years
1

About this medicine

Type: medicine.

Questions owners ask

Can Ketoconazole cause eosinopenia in dogs?
30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 111 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eosinopenia with similar medicines

All reported side effects of Ketoconazole in dogs · Medicines most reported with eosinopenia