Leukopenia after Ketoconazole in dogs

23 reports to the FDA describe leukopenia in dogs given Ketoconazole. That is 1.0% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

23Reports

26%Marked serious

17%Recovered

13%Died or euthanised

61 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

0 0.0%

3–7 days

0 0.0%

1–4 weeks

6 26%

Over a month

17 74%

How the animals did

Recovered

4 17%

Still unwell when reported

10 43%

Died

3 13%

Not known

6 26%

Problems reported at the same time

18 78%

13 57%

13 57%

8 35%

Decreased haematocrit

8 35%

Lethargy

7 30%

Liver problems

7 30%

Increased percentage reticulocytes

6 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Ketoconazole cause leukopenia in dogs?: 23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 61 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Ketoconazole in dogs · Medicines most reported with leukopenia