Vomiting after Imidacloprid + Permethrin in dogs

The FDA has received 139 reports of vomiting in dogs after Imidacloprid + Permethrin. That is 30% of all reports for this medicine, compared with 28% across reports for all dog medicines.

139Reports

21%Marked serious

69%Recovered

3.6%Died or euthanised

22 daysTypical onset

How soon it started

Same day

27 23%

1–2 days

10 8.6%

3–7 days

8 6.9%

1–4 weeks

18 16%

Over a month

53 46%

How the animals did

Recovered

92 66%

Recovered with lasting effects

4 2.9%

Still unwell when reported

14 10%

Died

3 2.2%

Euthanised

2 1.4%

Not known

24 17%

Problems reported at the same time

35 25%

20 14%

19 14%

12 8.6%

10 7.2%

Tremors

9 6.5%

Drooling

9 6.5%

Behaviour change

8 5.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Permethrin cause vomiting in dogs?: 139 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 22 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Spinosad (Comfortis) 30,909 reports · 54% of its reports
Vomiting after Lufenuron + Milbemycin Oxime (Sentinel) 4,725 reports · 18% of its reports
Vomiting after Imidacloprid + Moxidectin (Advantage Multi) 1,904 reports · 15% of its reports
Vomiting after Nitenpyram (Capstar) 1,204 reports · 11% of its reports
Vomiting after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 1,925 reports · 19% of its reports
Vomiting after Fipronil + S-methoprene (Frontline Plus) 627 reports · 21% of its reports
Vomiting after Flumethrin + Imidacloprid (Seresto) 295 reports · 13% of its reports
Vomiting after Imidacloprid 251 reports · 13% of its reports
Vomiting after Fipronil 417 reports · 30% of its reports
Vomiting after Lufenuron 325 reports · 32% of its reports

All reported side effects of Imidacloprid + Permethrin in dogs · Medicines most reported with vomiting