Loss of appetite after Imidacloprid + Permethrin in dogs

The FDA has received 47 reports of loss of appetite in dogs after Imidacloprid + Permethrin. That is 10% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

47Reports
34%Marked serious
51%Recovered
11%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
8 24%
1–2 days
8 24%
3–7 days
4 12%
1–4 weeks
4 12%
Over a month
9 27%

How the animals did

Recovered
20 43%
Recovered with lasting effects
4 8.5%
Still unwell when reported
12 26%
Died
3 6.4%
Euthanised
2 4.3%
Not known
6 13%

Problems reported at the same time

29 62%
19 40%
12 26%
Not drinking
7 15%
Weight loss
6 13%
Fever
5 11%

Age of the animals

Under 1 year
6
1–3 years
15
4–7 years
8
8–11 years
9
12+ years
7

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Permethrin cause loss of appetite in dogs?
47 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Imidacloprid + Permethrin in dogs · Medicines most reported with loss of appetite