Seizures after Ilunocitinib (Zenrelia) in dogs

76 reports to the FDA describe seizures in dogs given Ilunocitinib. That is 3.5% of all reports for this medicine, compared with 4.4% across reports for all dog medicines.

76Reports

99%Marked serious

42%Recovered

14%Died or euthanised

30 daysTypical onset

How soon it started

Same day

6 9.8%

1–2 days

2 3.3%

3–7 days

6 9.8%

1–4 weeks

18 30%

Over a month

29 48%

How the animals did

Recovered

32 42%

Still unwell when reported

16 21%

Died

9 12%

Euthanised

2 2.6%

Not known

17 22%

Problems reported at the same time

11 14%

11 14%

9 12%

9 12%

8 11%

8 11%

Didn't work as expected

7 9.2%

Vomiting

6 7.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause seizures in dogs?: 76 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 30 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

Seizures after Oclacitinib (Apoquel) 1,241 reports · 4.3% of its reports
Seizures after Cyclosporine (Atopica) 508 reports · 3.3% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with seizures