Seizures after Cyclosporine (Atopica) in dogs

The FDA has received 508 reports of seizures in dogs after Cyclosporine. That is 3.3% of all reports for this medicine, compared with 4.4% across reports for all dog medicines.

508Reports

38%Marked serious

20%Recovered

13%Died or euthanised

29 daysTypical onset

How soon it started

Same day

26 19%

1–2 days

8 6.0%

3–7 days

10 7.5%

1–4 weeks

24 18%

Over a month

66 49%

How the animals did

Recovered

93 18%

Recovered with lasting effects

8 1.6%

Still unwell when reported

41 8.1%

Died

39 7.7%

Euthanised

25 4.9%

Not known

302 59%

Problems reported at the same time

69 14%

65 13%

60 12%

44 8.7%

39 7.7%

39 7.7%

38 7.5%

30 5.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

177

8–11 years

158

12+ years

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause seizures in dogs?: 508 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 29 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

Seizures after Oclacitinib (Apoquel) 1,241 reports · 4.3% of its reports
Seizures after Ilunocitinib (Zenrelia) 76 reports · 3.5% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with seizures