Uncomfortable after Grapiprant (Galliprant) in dogs

The FDA has received 81 reports of uncomfortable in dogs after Grapiprant. That is 0.9% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

81Reports

57%Marked serious

20%Recovered

28%Died or euthanised

12 daysTypical onset

How soon it started

Same day

9 15%

1–2 days

4 6.5%

3–7 days

11 18%

1–4 weeks

23 37%

Over a month

15 24%

How the animals did

Recovered

16 20%

Still unwell when reported

30 37%

Died

7 8.6%

Euthanised

16 20%

Not known

12 15%

Problems reported at the same time

33 41%

31 38%

25 31%

23 28%

18 22%

16 20%

14 17%

14 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause uncomfortable in dogs?: 81 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 12 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Uncomfortable with similar medicines

Uncomfortable after Carprofen (Rimadyl) 101 reports · 0.2% of its reports

All reported side effects of Grapiprant in dogs · Medicines most reported with uncomfortable