Pain after Grapiprant (Galliprant) in dogs

The FDA has received 194 reports of pain in dogs after Grapiprant. That is 2.2% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

194Reports
55%Marked serious
8.2%Recovered
26%Died or euthanised
18 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
32 21%
1–2 days
9 5.9%
3–7 days
19 13%
1–4 weeks
28 18%
Over a month
64 42%

How the animals did

Recovered
16 8.2%
Still unwell when reported
81 42%
Died
10 5.2%
Euthanised
41 21%
Not known
46 24%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
5
4–7 years
18
8–11 years
62
12+ years
91

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause pain in dogs?
194 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 18 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pain with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with pain