Swelling after Grapiprant (Galliprant) in dogs

The FDA has received 188 reports of swelling in dogs after Grapiprant. That is 2.1% of all reports for this medicine, compared with 2.8% across reports for all dog medicines.

188Reports
54%Marked serious
14%Recovered
16%Died or euthanised
21 daysTypical onset
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How soon it started

Same day
29 20%
1–2 days
18 12%
3–7 days
8 5.4%
1–4 weeks
33 22%
Over a month
59 40%

How the animals did

Recovered
26 14%
Recovered with lasting effects
1 0.5%
Still unwell when reported
93 49%
Died
12 6.4%
Euthanised
19 10%
Not known
37 20%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
10
4–7 years
30
8–11 years
82
12+ years
58

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause swelling in dogs?
188 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 21 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with swelling