Sleepiness - systemic disorder after Grapiprant (Galliprant) in dogs

The FDA has received 64 reports of sleepiness - systemic disorder in dogs after Grapiprant. That is 0.7% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

64Reports
23%Marked serious
27%Recovered
13%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
16 30%
1–2 days
8 15%
3–7 days
6 11%
1–4 weeks
7 13%
Over a month
16 30%

How the animals did

Recovered
17 27%
Still unwell when reported
24 38%
Died
3 4.7%
Euthanised
5 7.8%
Not known
15 23%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
3
4–7 years
4
8–11 years
13
12+ years
40

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause sleepiness - systemic disorder in dogs?
64 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Sleepiness - systemic disorder with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with sleepiness - systemic disorder