Disorientation after Grapiprant (Galliprant) in dogs

179 reports to the FDA describe disorientation in dogs given Grapiprant. That is 2.0% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

179Reports
61%Marked serious
23%Recovered
27%Died or euthanised
23 daysTypical onset
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How soon it started

Same day
26 20%
1–2 days
7 5.3%
3–7 days
17 13%
1–4 weeks
21 16%
Over a month
61 46%

How the animals did

Recovered
40 22%
Recovered with lasting effects
1 0.6%
Still unwell when reported
56 31%
Died
6 3.4%
Euthanised
43 24%
Not known
33 18%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
16
8–11 years
40
12+ years
116

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause disorientation in dogs?
179 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 23 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with disorientation