Seizures after Grapiprant (Galliprant) in dogs

396 reports to the FDA describe seizures in dogs given Grapiprant. That is 4.5% of all reports for this medicine, compared with 4.4% across reports for all dog medicines.

396Reports
87%Marked serious
29%Recovered
26%Died or euthanised
21 daysTypical onset
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How soon it started

Same day
37 12%
1–2 days
32 11%
3–7 days
45 15%
1–4 weeks
47 16%
Over a month
136 46%

How the animals did

Recovered
115 29%
Still unwell when reported
116 29%
Died
27 6.8%
Euthanised
77 19%
Not known
61 15%

Problems reported at the same time

Age of the animals

Under 1 year
3
1–3 years
5
4–7 years
32
8–11 years
118
12+ years
231

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause seizures in dogs?
396 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 21 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with seizures