Tremors after Grapiprant (Galliprant) in dogs

The FDA has received 245 reports of tremors in dogs after Grapiprant. That is 2.8% of all reports for this medicine, compared with 3.4% across reports for all dog medicines.

245Reports
54%Marked serious
31%Recovered
22%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
47 24%
1–2 days
32 16%
3–7 days
24 12%
1–4 weeks
21 11%
Over a month
72 37%

How the animals did

Recovered
75 31%
Recovered with lasting effects
2 0.8%
Still unwell when reported
81 33%
Died
20 8.2%
Euthanised
35 14%
Not known
32 13%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
7
4–7 years
13
8–11 years
88
12+ years
127

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause tremors in dogs?
245 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tremors with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with tremors