Pacing after Grapiprant (Galliprant) in dogs

The FDA has received 87 reports of pacing in dogs after Grapiprant. That is 1.0% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

87Reports
54%Marked serious
28%Recovered
26%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
12 20%
1–2 days
14 23%
3–7 days
5 8.2%
1–4 weeks
8 13%
Over a month
22 36%

How the animals did

Recovered
24 28%
Still unwell when reported
24 28%
Died
4 4.6%
Euthanised
19 22%
Not known
16 18%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
4
8–11 years
34
12+ years
46

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause pacing in dogs?
87 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pacing with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with pacing