Neurological disorder after Grapiprant (Galliprant) in dogs

The FDA has received 27 reports of neurological disorder in dogs after Grapiprant. That is 0.3% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

27Reports

85%Marked serious

7.4%Recovered

52%Died or euthanised

10 daysTypical onset

How soon it started

Same day

7 29%

1–2 days

4 17%

3–7 days

1 4.2%

1–4 weeks

7 29%

Over a month

5 21%

How the animals did

Recovered

2 7.4%

Still unwell when reported

10 37%

Died

2 7.4%

Euthanised

12 44%

Not known

1 3.7%

Problems reported at the same time

14 52%

11 41%

8 30%

7 26%

7 26%

5 19%

5 19%

5 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause neurological disorder in dogs?: 27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 10 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neurological disorder with similar medicines

Neurological disorder after Carprofen (Rimadyl) 35 reports · 0.1% of its reports

All reported side effects of Grapiprant in dogs · Medicines most reported with neurological disorder