Elevated amylase after Grapiprant (Galliprant) in dogs

54 reports to the FDA describe elevated amylase in dogs given Grapiprant. That is 0.6% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

54Reports
74%Marked serious
7.4%Recovered
22%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
5 12%
1–2 days
1 2.4%
3–7 days
6 15%
1–4 weeks
8 20%
Over a month
21 51%

How the animals did

Recovered
4 7.4%
Still unwell when reported
29 54%
Died
2 3.7%
Euthanised
10 19%
Not known
9 17%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
10
8–11 years
17
12+ years
26

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause elevated amylase in dogs?
54 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated amylase with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with elevated amylase