Drooling after Grapiprant (Galliprant) in dogs

The FDA has received 132 reports of drooling in dogs after Grapiprant. That is 1.5% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

132Reports
55%Marked serious
24%Recovered
23%Died or euthanised
10 daysTypical onset
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How soon it started

Same day
25 24%
1–2 days
15 15%
3–7 days
8 7.8%
1–4 weeks
18 17%
Over a month
37 36%

How the animals did

Recovered
32 24%
Still unwell when reported
45 34%
Died
6 4.5%
Euthanised
24 18%
Not known
25 19%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
4
4–7 years
19
8–11 years
58
12+ years
49

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause drooling in dogs?
132 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 10 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with drooling