Decreased urine concentration after Grapiprant (Galliprant) in dogs

The FDA has received 92 reports of decreased urine concentration in dogs after Grapiprant. That is 1.0% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

92Reports

51%Marked serious

4.3%Recovered

12%Died or euthanised

49 daysTypical onset

How soon it started

Same day

7 11%

1–2 days

6 9.4%

3–7 days

0 0.0%

1–4 weeks

12 19%

Over a month

39 61%

How the animals did

Recovered

3 3.3%

Recovered with lasting effects

1 1.1%

Still unwell when reported

52 57%

Died

1 1.1%

Euthanised

10 11%

Not known

25 27%

Problems reported at the same time

51 55%

39 42%

29 32%

29 32%

28 30%

19 21%

17 18%

Didn't work as expected

14 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause decreased urine concentration in dogs?: 92 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 49 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased urine concentration with similar medicines

Decreased urine concentration after Carprofen (Rimadyl) 888 reports · 1.9% of its reports
Decreased urine concentration after Deracoxib (Deramaxx) 465 reports · 4.2% of its reports
Decreased urine concentration after Meloxicam (Metacam) 140 reports · 1.7% of its reports
Decreased urine concentration after Firocoxib (Previcox) 174 reports · 2.2% of its reports

All reported side effects of Grapiprant in dogs · Medicines most reported with decreased urine concentration