Collapse after Grapiprant (Galliprant) in dogs

142 reports to the FDA describe collapse in dogs given Grapiprant. That is 1.6% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported unusually often with this medicine.

142Reports
89%Marked serious
13%Recovered
32%Died or euthanised
34 daysTypical onset
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How soon it started

Same day
16 15%
1–2 days
7 6.4%
3–7 days
11 10%
1–4 weeks
20 18%
Over a month
56 51%

How the animals did

Recovered
18 13%
Still unwell when reported
57 40%
Died
21 15%
Euthanised
24 17%
Not known
22 15%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
3
4–7 years
9
8–11 years
55
12+ years
73

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause collapse in dogs?
142 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 34 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with collapse