Cardiac enlargement after Grapiprant (Galliprant) in dogs
The FDA has received 21 reports of cardiac enlargement in dogs after Grapiprant. That is 0.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.
21Reports
90%Marked serious
0.0%Recovered
33%Died or euthanised
24 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).
Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.
Questions owners ask
- Can Grapiprant cause cardiac enlargement in dogs?
- 21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 24 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Cardiac enlargement with similar medicines
- Cardiac enlargement after Carprofen (Rimadyl) 100 reports · 0.2% of its reports
- Cardiac enlargement after Deracoxib (Deramaxx) 25 reports · 0.2% of its reports
All reported side effects of Grapiprant in dogs · Medicines most reported with cardiac enlargement