Abnormal radiograph finding after Grapiprant (Galliprant) in dogs

The FDA has received 220 reports of abnormal radiograph finding in dogs after Grapiprant. That is 2.5% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported unusually often with this medicine.

220Reports

79%Marked serious

4.5%Recovered

30%Died or euthanised

30 daysTypical onset

How soon it started

Same day

15 9.8%

1–2 days

18 12%

3–7 days

16 10%

1–4 weeks

29 19%

Over a month

75 49%

How the animals did

Recovered

10 4.5%

Still unwell when reported

119 54%

Died

15 6.8%

Euthanised

50 23%

Not known

26 12%

Problems reported at the same time

77 35%

73 33%

68 31%

64 29%

57 26%

51 23%

45 20%

37 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause abnormal radiograph finding in dogs?: 220 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 30 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal radiograph finding with similar medicines

Abnormal radiograph finding after Carprofen (Rimadyl) 1,500 reports · 3.2% of its reports
Abnormal radiograph finding after Deracoxib (Deramaxx) 700 reports · 6.4% of its reports
Abnormal radiograph finding after Meloxicam (Metacam) 209 reports · 2.6% of its reports
Abnormal radiograph finding after Firocoxib (Previcox) 247 reports · 3.1% of its reports

All reported side effects of Grapiprant in dogs · Medicines most reported with abnormal radiograph finding