Recumbency after Grapiprant (Galliprant) in dogs

The FDA has received 40 reports of recumbency in dogs after Grapiprant. That is 0.5% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

40Reports
88%Marked serious
2.5%Recovered
53%Died or euthanised
24 daysTypical onset
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How soon it started

Same day
5 16%
1–2 days
2 6.5%
3–7 days
5 16%
1–4 weeks
9 29%
Over a month
10 32%

How the animals did

Recovered
1 2.5%
Still unwell when reported
11 28%
Died
2 5.0%
Euthanised
19 48%
Not known
7 18%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
3
8–11 years
19
12+ years
17

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause recumbency in dogs?
40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 24 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Recumbency with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with recumbency