Underdose after Fluoxetine in dogs

The FDA has received 43 reports of underdose in dogs after Fluoxetine. That is 1.7% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

43Reports

42%Marked serious

33%Recovered

4.7%Died or euthanised

14 daysTypical onset

How soon it started

Same day

7 24%

1–2 days

2 6.9%

3–7 days

5 17%

1–4 weeks

5 17%

Over a month

10 34%

How the animals did

Recovered

14 33%

Still unwell when reported

6 14%

Died

1 2.3%

Euthanised

1 2.3%

Not known

21 49%

Problems reported at the same time

Didn't work as expected

15 35%

Loss of appetite

10 23%

Tremors

6 14%

Seizures

6 14%

Restlessness or agitation

5 12%

Medication error

5 12%

Breathing problems

4 9.3%

Anxiety

4 9.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fluoxetine treats anxiety and behaviour problems.

Questions owners ask

Can Fluoxetine cause underdose in dogs?: 43 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Underdose with similar medicines

Underdose after Gabapentin 159 reports · 1.8% of its reports
Underdose after Selegiline (Anipryl) 20 reports · 0.5% of its reports
Underdose after Trazodone 47 reports · 1.9% of its reports
Underdose after Clomipramine (Clomicalm) 27 reports · 1.8% of its reports

All reported side effects of Fluoxetine in dogs · Medicines most reported with underdose