Hyperglycaemia after Doxycycline in dogs

The FDA has received 51 reports of hyperglycaemia in dogs after Doxycycline. That is 1.3% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

51Reports

84%Marked serious

16%Recovered

33%Died or euthanised

11 daysTypical onset

How soon it started

Same day

6 13%

1–2 days

6 13%

3–7 days

8 17%

1–4 weeks

8 17%

Over a month

19 40%

How the animals did

Recovered

6 12%

Recovered with lasting effects

2 3.9%

Still unwell when reported

17 33%

Died

7 14%

Euthanised

10 20%

Not known

9 18%

Problems reported at the same time

33 65%

28 55%

23 45%

22 43%

22 43%

21 41%

18 35%

18 35%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause hyperglycaemia in dogs?: 51 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 11 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperglycaemia with similar medicines

Hyperglycaemia after Amoxicillin + Clavulanate (Clavamox) 100 reports · 1.9% of its reports
Hyperglycaemia after Cefovecin (Convenia) 63 reports · 1.7% of its reports
Hyperglycaemia after Enrofloxacin (Baytril) 72 reports · 1.9% of its reports
Hyperglycaemia after Metronidazole 56 reports · 1.8% of its reports
Hyperglycaemia after Amoxicillin 42 reports · 3.1% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with hyperglycaemia