Sleepiness - systemic disorder after Diphenhydramine in dogs

27 reports to the FDA describe sleepiness - systemic disorder in dogs given Diphenhydramine. That is 0.6% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

27Reports

59%Marked serious

30%Recovered

3.7%Died or euthanised

1 daysTypical onset

How soon it started

Same day

12 48%

1–2 days

4 16%

3–7 days

4 16%

1–4 weeks

1 4.0%

Over a month

4 16%

How the animals did

Recovered

8 30%

Still unwell when reported

7 26%

Died

1 3.7%

Not known

11 41%

Problems reported at the same time

9 33%

9 33%

8 30%

8 30%

7 26%

7 26%

6 22%

Injection site reaction

5 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause sleepiness - systemic disorder in dogs?: 27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Sleepiness - systemic disorder with similar medicines

Sleepiness - systemic disorder after Polysulfated Glycosaminoglycan 27 reports · 0.5% of its reports
Sleepiness - systemic disorder after Butorphanol 23 reports · 0.5% of its reports

All reported side effects of Diphenhydramine in dogs · Medicines most reported with sleepiness - systemic disorder