Increased heart rate after Diphenhydramine in dogs

43 reports to the FDA describe increased heart rate in dogs given Diphenhydramine. That is 0.9% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

43Reports
81%Marked serious
26%Recovered
30%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
19 53%
1–2 days
4 11%
3–7 days
3 8.3%
1–4 weeks
2 5.6%
Over a month
8 22%

How the animals did

Recovered
11 26%
Still unwell when reported
11 26%
Died
4 9.3%
Euthanised
9 21%
Not known
8 19%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
8
4–7 years
8
8–11 years
17
12+ years
8

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause increased heart rate in dogs?
43 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Increased heart rate with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with increased heart rate