Hyponatremia after Diphenhydramine in dogs
The FDA has received 43 reports of hyponatremia in dogs after Diphenhydramine. That is 0.9% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.
43Reports
91%Marked serious
2.3%Recovered
56%Died or euthanised
2 daysTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Type: medicine.
Questions owners ask
- Can Diphenhydramine cause hyponatremia in dogs?
- 43 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 2 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Hyponatremia with similar medicines
- Hyponatremia after Melarsomine (Immiticide) 29 reports · 0.1% of its reports
- Hyponatremia after Butorphanol 33 reports · 0.7% of its reports
- Hyponatremia after Cefpodoxime 25 reports · 0.6% of its reports
- Hyponatremia after Tramadol 34 reports · 0.9% of its reports
- Hyponatremia after Desoxycorticosterone Pivalate 124 reports · 3.7% of its reports
- Hyponatremia after Propofol 25 reports · 0.8% of its reports
- Hyponatremia after Famotidine 40 reports · 1.5% of its reports
- Hyponatremia after Furosemide 21 reports · 1.4% of its reports
- Hyponatremia after Sucralfate 24 reports · 2.4% of its reports
- Hyponatremia after Ampicillin 51 reports · 5.2% of its reports
All reported side effects of Diphenhydramine in dogs · Medicines most reported with hyponatremia