Hyponatremia after Melarsomine (Immiticide) in dogs

The FDA has received 29 reports of hyponatremia in dogs after Melarsomine. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

29Reports

59%Marked serious

3.4%Recovered

31%Died or euthanised

22 daysTypical onset

How soon it started

Same day

2 9.5%

1–2 days

3 14%

3–7 days

2 9.5%

1–4 weeks

5 24%

Over a month

9 43%

How the animals did

Recovered

1 3.4%

Still unwell when reported

8 28%

Died

7 24%

Euthanised

2 6.9%

Not known

11 38%

Problems reported at the same time

23 79%

20 69%

18 62%

13 45%

13 45%

12 41%

11 38%

10 34%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Melarsomine treats adult heartworm infection (a series of injections given by a vet).

Products with this ingredient include Immiticide, Diroban. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Melarsomine cause hyponatremia in dogs?: 29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 22 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyponatremia with similar medicines

Hyponatremia after Diphenhydramine 43 reports · 0.9% of its reports
Hyponatremia after Butorphanol 33 reports · 0.7% of its reports
Hyponatremia after Cefpodoxime 25 reports · 0.6% of its reports
Hyponatremia after Tramadol 34 reports · 0.9% of its reports
Hyponatremia after Desoxycorticosterone Pivalate 124 reports · 3.7% of its reports
Hyponatremia after Propofol 25 reports · 0.8% of its reports
Hyponatremia after Famotidine 40 reports · 1.5% of its reports
Hyponatremia after Furosemide 21 reports · 1.4% of its reports
Hyponatremia after Sucralfate 24 reports · 2.4% of its reports
Hyponatremia after Ampicillin 51 reports · 5.2% of its reports

All reported side effects of Melarsomine in dogs · Medicines most reported with hyponatremia