Crust after Diphenhydramine in dogs

49 reports to the FDA describe crust in dogs given Diphenhydramine. That is 1.0% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

49Reports
71%Marked serious
4.1%Recovered
4.1%Died or euthanised
13 daysTypical onset
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How soon it started

Same day
7 18%
1–2 days
4 10%
3–7 days
7 18%
1–4 weeks
6 15%
Over a month
15 38%

How the animals did

Recovered
1 2.0%
Recovered with lasting effects
1 2.0%
Still unwell when reported
31 63%
Euthanised
2 4.1%
Not known
14 29%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
7
4–7 years
16
8–11 years
18
12+ years
5

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause crust in dogs?
49 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 13 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Crust with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with crust